期刊
CLINICAL IMMUNOLOGY
卷 118, 期 1, 页码 1-10出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2005.10.011
关键词
natural killer cells; innate immunity; cytotoxicity; killer cell immunoglobulin-like receptors; immunodeficiency
类别
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K08AI055602] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI-055602] Funding Source: Medline
Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host defense and immune regulation. They are activated or inhibited through the ligation of germline-encoded receptors and are involved in mediating cytotoxicity, in producing cytokines and in providing co-stimulation to cells of the adaptive immune system. NK cells play important roles in viral infections, autoimmunity, pregnancy, cancer and bone marrow transplantation. This review highlights recent developments in the understanding of the role of human NK cells in health and disease. Published by Elsevier Inc.
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