期刊
JOURNAL OF NUTRITION
卷 136, 期 1, 页码 172-176出版社
OXFORD UNIV PRESS
DOI: 10.1093/jn/136.1.172
关键词
aging; carotenoids; mortality; selenium women
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000722] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041956] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R37AG019905, R01AG011703, R01AG027012, N01AG012112] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR00722] Funding Source: Medline
- NIAID NIH HHS [R01 AI41956] Funding Source: Medline
- NIA NIH HHS [R01 AG027012, R01 AG027012-01, R37 AG019905, R01 AG11703-01A1, N01-AG12112] Funding Source: Medline
Selenium and the carotenoids play an important role in antioxidant defenses and in the redox regulation involved in inflammation. We tested the hypothesis that low selenium and carotenoids predict mortality in older women living in the community. Women who were enrolled in the Women's Health and Aging Studies I and 11 in Baltimore, MD (n = 632; 70-79 y old) had serum selenium and carotenoids measured at baseline and were followed for mortality over 60 mo. Median (minimum, maximum) serum selenium and carotenoids were 1.53 (0.73, 2,51) mu mol/L and 1.67 (0.13, 9.10) mu mol/L; 14.1% of the women died. The 5 major causes of death were heart disease (32.6%), cancer (118.0%), stroke (9.0%), infection (6.7%), and chronic obstructive pulmonary disease (5.6%). Adjusting for age, education, smoking, BMI, poor appetite, and chronic diseases, higher serum selenium [hazard ratio (HR) 0.71, 95% Cl 0.56-0.90/1 SD increase in log. selenium; P = 0.005] and higher serum total carotenoids (HR 0.77, 95% Cl 0.64-0.84/1 SD increase in log, total carotenolds; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据