期刊
ACTA PAEDIATRICA
卷 95, 期 9, 页码 1036-1048出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/08035250600615168
关键词
paediatrics; respiratory distress syndrome; surfactant therapy
类别
This review documents the evolution of surfactant therapy, beginning with observations of surfactant deficiency in respiratory distress syndrome, the basis of exogenous surfactant treatment and the development of surfactant-containing novel peptides patterned after SP-B. We critically analyse the molecular interactions of surfactant proteins and phospholipids contributing to surfactant function. Conclusion: Peptide-containing surfactant provides clinical efficacy in the treatment of respiratory distress syndrome and offers promise for treating other lung diseases in infancy.
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