期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 84, 期 3, 页码 475-482出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/84.3.475
关键词
strength; muscle; protein metabolism; sarcopenia; dietary requirements
资金
- NIAMS NIH HHS [R01 AR49038] Funding Source: Medline
- NIA NIH HHS [P30 AG024832] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR049038] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG024832] Funding Source: NIH RePORTER
Muscle plays a central role in whole-body protein metabolism by serving as the principal reservoir for amino acids to maintain protein synthesis in vital tissues and organs in the absence of amino acid absorption from the gut and by providing hepatic gluconeogenic precursors. Furthermore, altered muscle metabolism plays a key role in the genesis, and therefore the prevention, of many common pathologic conditions and chronic diseases. Nonetheless, the maintenance of adequate muscle mass, strength, and metabolic function has rarely, if ever, been targeted as a relevant endpoint of recommendations for dietary intake. It is therefore imperative that factors directly related to muscle mass, strength, and metabolic function be included in future studies designed to demonstrate optimal lifestyle behaviors throughout the life span, including physical activity and diet.
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