4.3 Article

Efficient synthesis of bifenazate

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SYNTHETIC COMMUNICATIONS
卷 36, 期 15, 页码 2151-2156

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TAYLOR & FRANCIS INC
DOI: 10.1080/00397910600636683

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bifenazate; diisopropyl azodicarboxylate; fluoroalcohols; 4-methoxybiphenyl; nitromethane

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The synthesis of bifenazate using a two-step procedure has been accomplished with an overall yield of 26%. The procedure involved the Lewis acid-catalyzed electrophilic aromatic substitution of 4-methoxybiphenyl with diisopropyl azodicarcoxylate (DIAD) to give a hydrazinedicarboxylate intermediate that was then subjected to a decarboxylation reaction to give bifenazate.

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