期刊
JOURNAL OF PEDIATRICS
卷 148, 期 1, 页码 30-37出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2005.08.023
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资金
- NCRR NIH HHS [S06-RR08167] Funding Source: Medline
- NIAAA NIH HHS [R01-AA09524, P50-AA07606, R01-AA06966] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S06RR008167] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA009524, P50AA007606, R01AA006966] Funding Source: NIH RePORTER
Objectives To examine alcohol use for mothers with and without an ADH1B*3 allele and the moderating effects of the maternal and child ADH1B*3 allele on a broad range of infant and 7.5-year outcomes. Study design Blood samples from 263 black mother/child pairs (217 mothers and 239 children) were analyzed to determine incidence of the ADH1B allele and the relation of the maternal allele to pregnancy drinking assessed at every prenatal clinic visit. Moderating effects of ADH1B were examined by dichotomizing the moderator variable and performing regression analyses on the 2 groups. Results Pregnancy drinking at conception was less frequent in the presence of the ADH1B*3 allele, and virtually no adverse effects were found in children whose mothers had at least one ADH1B*3 allele. By contrast to the maternal allele, we found no consistent pattern of greater vulnerability in children lacking the ADH1B*3 allele. Conclusions These data are consistent with the hypothesis that the maternal ADH1B*3 allele provides some protection to the fetus from prenatal alcohol exposure.
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