期刊
LEUKEMIA
卷 20, 期 1, 页码 128-135出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.leu.2404010
关键词
myelodysplastic syndrome; hemopoietic cell transplantation; nonmyeloablative transplantation; secondary leukemia
资金
- NATIONAL CANCER INSTITUTE [P30CA015704, P01CA018029, P01CA078902] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL036444] Funding Source: NIH RePORTER
- NCI NIH HHS [CA18029, P01 CA078902, CA78902, CA15704] Funding Source: Medline
- NHLBI NIH HHS [HL36444] Funding Source: Medline
Transplant outcome was analyzed in 150 patients with myelo-dysplastic syndrome (MDS) or acute myelogenous leukemia transformed from MDS (tAML) conditioned with nonmyeloablative or myeloablative regimens. A total of 38 patients received nonmyeloablative regimens of 2Gy total body irradiation alone (n = 2) or with fludarabine (n = 36), 90mg/m(2). A total of 112 patients received a myeloablative regimen of busulfan, 16 mg/kg ( targeted to 800-900 ng/ml), and cyclophosphamide 120 mg/kg. Nonmyeloablative patients were older ( median age 62 vs 52 years, P < 0.001), more frequently had progressed to tAML ( 53 vs 31%, P = 0.06), had higher risk disease by the International Prognostic Scoring System ( 53 vs 30%, P = 0.004), had higher transplant specific comorbidity indices ( 68 vs 42%, P = 0.01) and more frequently had durable complete responses to induction chemotherapy ( 58 vs 14%). Three-year overall survival (27%/48% ( P = 0.56)), progression-free survival (28%/44%, ( P = 0.60)), and nonrelapse mortality (41%/34%, ( P = 0.94)) did not differ significantly between nonmyeloblative/ myeloablative conditioning. Overall (HR = 0.9, P = 0.84) and progression-free survivals (HR = 1, P = 0.93) were similar for patients with chemotherapy-induced remissions irrespective of conditioning intensity. Graft vs leukemia effects may be more important than conditioning intensity in preventing progression in patients in chemotherapy-induced remissions at the time of transplantation. Randomized prospective studies are needed to further address the optimal choice of transplant conditioning intensity in myeloid neoplasms.
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