期刊
FEMS MICROBIOLOGY LETTERS
卷 254, 期 2, 页码 300-307出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1574-6968.2005.00041.x
关键词
Listeria monocytogenes; ActA; allelic variation; virulence
类别
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063259] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01GM63259] Funding Source: Medline
To test the hypothesis that actA allelic variation contributes to virulence differences among Listeria monocytogenes strains, cell-to-cell spread and intracellular ActA phosphorylation patterns were characterized for 14 wild-type isolates and selected isogenic mutants. Our data show that (i) while actA allelic variation is not responsible for enhanced cell-to-cell spread observed in epidemic clone I strains, actA allelic variation may contribute to reduced plaque size observed in some isolates, (ii) actA sequence alone determines phosphorylation-dependent ActA banding patterns, and (iii) sequence variation at the positively selected ActA residue 498 does not contribute to ActA phosphorylation patterns or to differences in cell-to-cell spread.
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