期刊
EXPERIMENTAL NEUROLOGY
卷 197, 期 1, 页码 225-234出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2005.09.013
关键词
pudendal nerve; bladder; electrical stimulation; spinal cord injury; cat
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD039768] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068566, R56DK068566] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS045078] Funding Source: NIH RePORTER
- NICHD NIH HHS [1PO1-HD-39768-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK068566-03, R01 DK068566-01, R01 DK068566-04A2, 1R01-DK-068566-01, R01 DK068566, R01 DK068566-02, R56 DK068566, R56 DK068566-04A1] Funding Source: Medline
- NINDS NIH HHS [1R01-NS-045078-01] Funding Source: Medline
The effects of pudendal nerve stimulation on reflex bladder activity were investigated in cats with chronic spinal cord injury (6- 12 months) under alpha-chloralose anesthesia. Electrical stimulation of the pudendal nerve on one side at different frequencies and intensities induced either inhibitory or excitatory effects on bladder activity. The inhibitory effect peaked at a stimulation frequency of 3 Hz and gradually decreased at lower or higher frequencies. The inhibitory effect could occur at stimulation intensities between 0.3 and 1 V (pulse width 0.1 ms) and increased at intensities tip to 10 V Stimulation of the central end of transected pudendal nerve also inhibited bladder activity, indicating that afferent axons in pudendal nerve are involved. Nerve transections also showed that both hypogastric and pelvic nerves might be involved in the inhibitory pudendal-to-bladder spinal reflex. Pudendal nerve stimulation at 20 Hz and at the same intensities (1 - 10 V) elicited a bladder excitatory response. Although this excitatory effect Could not sustain a long lasting bladder contraction at small bladder volumes, it did induce continuous rhythmic bladder contractions at large bladder Volumes. This study indicated the possibility of developing a neuroprosthetic device based on pudendal nerve electrical stimulation to restore micturition function after spinal cord injury. (c) 2005 Elsevier Inc. All rights reserved.
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