期刊
CELL CYCLE
卷 5, 期 1, 页码 11-13出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.5.1.2296
关键词
Cdk1; cyclin B1; CKI; separase; securin; cohesin; prophase pathway; shugoshin; chromosome segregation; mitosis; meiosis
类别
Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, nonproteolytic functions of separase.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据