期刊
MAGNETIC RESONANCE IN MEDICINE
卷 55, 期 1, 页码 203-209出版社
WILEY
DOI: 10.1002/mrm.20702
关键词
MRI; acute myocardial infarction; SPIO; embryonic stem cells; in vivo imaging
资金
- NHLBI NIH HHS [5K23 HL04338-02] Funding Source: Medline
- NINDS NIH HHS [R01 NS 045062] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K23HL004338] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS045062] Funding Source: NIH RePORTER
Cell therapy has demonstrated the potential to restore injured myocardium. A reliable in vivo imaging method to localize transplanted cells and monitor their restorative effects will enable a systematic investigation of this therapeutic modality. The dual MRI capability of imaging both magnetically labeled mouse embryonic stem cells (mESC) and their restorative effects on cardiac function in a murine model of acute myocardial infarction is demonstrated. Serial in vivo MR detection of transplanted mESC and monitoring of the mESC-treated myocardium was conducted over a 4-week period using a 1.5 T clinical scanner. During the 4-week duration, the mESC-treated myocardium demonstrated sustained improvement of the left ventricular (LV) ejection fraction and conservation of LV mass. Furthermore, no significant difference of their restorative effects on the cardiac function was created by the magnetic labeling of mESC. Thus, in vivo MRI enables simultaneous detection of transplanted mESC and their therapeutic effect on the injured myocardium.
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