期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 1, 页码 83-92出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0503653
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资金
- NATIONAL CANCER INSTITUTE [R01CA047135] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA 47135, R01 CA047135, R01 CA047135-17] Funding Source: Medline
RHM1 (1) and RHM2 (2) are highly N-methylated linear octapeptides produced by an atypical strain of Acremonium sp., cultured from a marine sponge collected in Papua New Guinea. The known peptaibiotic efrapeptin G (3) was also isolated from this fungus. The planar structures of 1 and 2 were assigned based on 1D- and 2D-NMR experiments and fragmentation patterns from ESIMS. The absolute configuration of 1 was determined via Marfey's method; the absolute configuration of 2 is proposed to be identical. Efrapeptin G (3) displayed potent cytotoxicity against murine cancer cell lines. while RHMI (1) and RHM2 (2) showed weak cytotoxicity against murine cancer cell lines; efrapeptin G (3) and RHMI (1) also demonstrated antibacterial activity.
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