期刊
HUMAN MOLECULAR GENETICS
卷 15, 期 1, 页码 77-85出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddi428
关键词
-
资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002213] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG013846, R01AG009029] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01-HG/AG02213] Funding Source: Medline
- NIA NIH HHS [P30-AG13846, R01-AG09029] Funding Source: Medline
Paraoxonase is an arylesterase enzyme that is expressed in the liver and found in the circulation in association with apoA1 and the high-density lipoprotein, and prevents the accumulation of oxidized lipids in low-density lipoproteins in vitro. Common polymorphisms in genes encoding paraoxonase are established risk factors in a variety of vascular disorders including coronary artery disease and carotid artery stenosis, but their association with Alzheimer disease (AD) is controversial. We tested the association of 29 SNPs in PON1, PON2 and PON3 with AD in 730 Caucasian and 467 African American participants of the MIRAGE Study, an ongoing multi-center family-based genetic epidemiology study of AD. Eight SNPs were associated with AD in the African American families (0.0001 <= P <= 0.04) and two SNPs were associated with AD in Caucasian families (0.01 <= P <= 0.04). Of note, the pattern of association for the PON1 promoter SNP -161[C/T] was the same in both ethnic groups (P=0.006). Haplotype analysis using sliding windows revealed 11 contiguous SNP combinations spanning the three PON genes with significant global test scores (0.006 <= P <= 0.04) in the two ethnic groups combined. The most significantly associated haplotype comprised SNPs in the region spanning the -161[C/T] SNP (P=0.00009). Our results demonstrate association between AD and variants in the PON gene cluster in Caucasians and African Americans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据