期刊
HYPERTENSION IN PREGNANCY
卷 25, 期 2, 页码 73-80出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10641950600745137
关键词
MTHFR; C677T; preeclampsia; placental abruption; Finnish
Objective: The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia. Methods: 362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were genotyped for C677T polymorphism in the MTHFR gene. Results: Similar genotype distributions were observed in the frequencies of C/C homozygotes (58.6%, 64.1%, and 57.1% for the three groups, respectively) and mutant homozygotes T/T (9.0%, 5.1% and 5.4%). No significant differences were detected in T allele frequencies (25.2%, 20.5%, and 24.1% for the three groups, respectively). Conclusions: MTHFR C677T polymorphism does not have a major role in the development of preeclanipsia or placental abruption in the Finnish population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据