期刊
PEPTIDES
卷 27, 期 1, 页码 211-222出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2005.07.009
关键词
blood-brain barrier; adrenomedullin; angiotensin; endothelin; cytokine; substance P
资金
- NHLBI NIH HHS [HL-66074, HL-77731, HL-30260, HL-65380] Funding Source: Medline
- NIDDK NIH HHS [DK-62372] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL030260, R01HL065380, R01HL066074, R01HL077731] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062372] Funding Source: NIH RePORTER
A unique feature of cerebral endothelial cells (CECs) is the formation of the blood-brain barrier (BBB), which contributes to the stability of the brain microenvironment. CECs are capable of producing several substances mediating endothelium-dependent vasorelaxation or vasoconstriction, regulating BBB permeability, and participating in the regulation of cell-cell interactions during inflammatory and immunological processes. The chemical nature of these mediators produced by CECs ranges from gaseous anorganic molecules (e.g. nitric oxide) through lipid mediators (e.g. prostaglandins) to peptides. Peptide mediators are a large and diverse family of bioactive molecules which can elicit multiple effects on cerebral endothelial functions. in this review, we summarize current knowledge. of peptide mediators produced by CECs, such as adrenomedullin, angiotensin, endothelin and several others and their role in the regulation of BBB functions. (c) 2005 Elsevier Inc. All rights reserved.
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