期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 1, 页码 145-147出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0503597
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资金
- NCI NIH HHS [U19 CA052955, R01 CA047135-17, R01 CA047135, R01 CA 47135, U19 CA052955-10, CA 52955] Funding Source: Medline
- NCRR NIH HHS [S10 RR019918-018558, S10 RR019918, RR19918] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U19CA052955, U01CA052955, R01CA047135] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR019918] Funding Source: NIH RePORTER
A reinvestigation of the thiazole constituents from Cacospongia mycofijiensis, collected in Vanuatu, yielded known mycothiazole (3) plus a new derivative, mycothiazole-4,19-diol (6). The E stereochemistry at Delta(14,11) of 3 has been revised to Z and the structural features of 6 are elucidated. These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration.
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