期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 83, 期 1, 页码 1-6出版社
WILEY
DOI: 10.1002/jnr.20688
关键词
IGF-I; CNS; neural stem cells; progenitors; signaling transduction; development
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038891, R01NS048868] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS038891, NS048868] Funding Source: Medline
Insulin-like growth factor-I (IGF-I) plays a key role in normal development. Recent studies show that IGF-I exerts a wide variety actions in the central nervous system during development as well as in adulthood. This report reviews recent developments on IGF-I actions and its mechanisms in the central nervous system, with a focus on its actions during the development of neural stem cells and progenitors. Available data strongly indicate that IGF-I shortens the length of the cell cycle in neuron progenitors during embryonic life and has an influence on the growth of all neural cell types. The phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase pathways seem to be the predominant mediators of IGF-I-stimulated neural cell proliferation and survival. IGF-I actions, however, likely depend on cell type, developmental stage, and microenvironmental milieu. (c) 2005 Wiley-Liss, Inc.
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