Antiviral acyclic nucleoside phosphonates structure activity studies

This review concerns acyclic nucleoside phosphonates (ANP) and describes the concept of the design of isopolar and isosteric nucleotide analogues resistant towards degradation by enzymes in vivo. It describes the development of research which led to the discovery of several structurally related potent antivirals and ultimately resulted in the development of drugs directed against HIV, HBV and DNA-virus infections in general, namely adefovir, cidofovir and tenofovir. In addition to these classical compounds the review describes the present development in the field of ANP, the open-ring ANP and discusses the present achievements, concept of prodrug design and application. (c) 2006 Published by Elsevier B.V.