期刊
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
卷 98, 期 6, 页码 523-536出版社
WILEY
DOI: 10.1111/j.1742-7843.2006.pto_355.x
关键词
-
Topical corticosteroids remain the most efficacious single treatment for asthma and rhinitis. despite the emergence of newer drugs in recent years. The antiinflammatory properties of these products, combined with the targeting of formulations and optimization of the intrinsic pharmacokinetic features of the newer corticosteroid molecules has resulted in substantially improved airway selectivity. This review sets out to summarize the pharmacokinetic properties of inhaled corticosteroids that are important for the achievement of high levels of airway selectivity, with additional focus on the use of prodrugs/softdrugs relative to those of conventional corticosteroid molecules, mechanisms (such as esterification) by which retention at the target site is achieved white minimizing systemic exposure, and the role of plasma protein binding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据