期刊
PHARMACEUTICAL RESEARCH
卷 23, 期 6, 页码 1117-1132出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-006-0072-5
关键词
drug delivery; hormone replacement therapy; skin; testosterone; transdermal drug delivery
In the human male, testosterone is the major circulating androgen. The clinical effects of androgen are numerous, and testosterone deficiency is associated with a number of clinical abnormalities. At present, a variety of preparations containing testosterone is available for the treatment of androgen deficiency. Ideally, those treatments have to produce and maintain physiologic serum concentrations of the hormone. This article reviews the current existing testosterone dosage forms on the market with their advantages and drawbacks and examines new and emerging technology developments concerning this therapy. In particular, the latest innovations in transdermal delivery are explored.
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