期刊
NATURE NEUROSCIENCE
卷 9, 期 1, 页码 133-139出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1613
关键词
-
资金
- NICHD NIH HHS [HD-40722] Funding Source: Medline
- NIDA NIH HHS [DA-19627] Funding Source: Medline
- NIMH NIH HHS [MH-67396, MH-66734, MH-58616] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [F32HD040722] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH067396, R21MH066734] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA019627] Funding Source: NIH RePORTER
The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance-namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1- like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据