期刊
NATURE NEUROSCIENCE
卷 9, 期 1, 页码 28-30出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1611
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资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD035470] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR013642, C06RR012169] Funding Source: NIH RePORTER
- NCRR NIH HHS [RR08655, RR13642, C06 RR012169, P41 RR013642] Funding Source: Medline
- NICHD NIH HHS [P50 HD055784, P01 HD035470] Funding Source: Medline
To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.
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