期刊
NEUROPSYCHOLOGIA
卷 44, 期 10, 页码 1663-1673出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2006.03.030
关键词
dopamine; cognition; reward; punishment; flexibility; ventral striatum
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH063901] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS040813] Funding Source: NIH RePORTER
- NIMH NIH HHS [MH63901] Funding Source: Medline
- NINDS NIH HHS [NS40813] Funding Source: Medline
We investigated the role of dopamine in distinct forms of reversal shifting by comparing two groups of patients with mild Parkinson's disease (PD), one ON and one OFF their normal dopaminergic medication. In accordance with our previous work, patients ON medication exhibited impaired reversal shifting relative to patients OFF medication. The present results extend previous studies by showing that the medication-induced deficit on reversal shifting was restricted to conditions where reversals were signaled by unexpected punishment. By contrast, patients ON medication performed as well as patients OFF medication and controls when the reversal was signaled by unexpected reward. The medication-induced deficit was particularly pronounced in patients on the dopamine D3 receptor agonist pramipexole. These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes. (c) 2006 Elsevier Ltd. All rights reserved.
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