期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 23, 期 1, 页码 1-3出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msj006
关键词
nonsynonymous substitutions; novel genes; divergence times
It has recently been claimed that older genes tend to evolve more slowly than newer ones (Alba and Castresana 2005). By simulation of genes of equal age, we show that the inverse correlation between age and rate is an artifact caused by our inability to detect homology when evolutionary distances are large. Since evolutionary distance increases with time of divergence and rate of evolution, homologs of fast-evolving genes are frequently undetected in distantly related taxa and are, hence, misclassified as new. This misclassification causes the mean genetic distance of 'new' genes to be overestimated and the mean genetic distance of old genes to be underestimated.
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