期刊
NEUROPSYCHOLOGIA
卷 44, 期 10, 页码 1962-1977出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2006.01.037
关键词
attention; dopamine; striatum; feature search; conjunction search
资金
- NIDA NIH HHS [R29-DA11653] Funding Source: Medline
- NIMH NIH HHS [R21-MH066129] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R21MH066129] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R29DA011653] Funding Source: NIH RePORTER
Patients with Parkinson's disease (PD), a degenerative disorder primarily affecting the nigrostriatal dopamine system, exhibit deficits in selecting task-relevant stimuli in the presence of irrelevant stimuli, such as in visual search tasks. However, results from previous studies suggest that these deficits may vary as a function of whether selection must rely primarily on the bottom-up salience of the target relative to background stimuli, or whether top-down information about the identity of the target is available to bias selection. In the present study, moderate-to-severe medicated PD patients and age-matched controls were tested on six visual search tasks that systematically varied the relationship between bottom-up target salience (feature search, noisy feature search, conjunction search) and top-down target knowledge (Target Known versus Target Unknown). Comparison of slope and intercepts of the RT x set size function provided information about the efficiency of search and non-search (e.g., decision, response) components, respectively. Patients exhibited higher intercepts than controls as bottom-up target salience decreased, however these deficits were disproportionately larger under Target Unknown compared to Target Known conditions. Slope differences between PD and controls were limited to the Target Unknown Conjunction condition, where patients exhibited a shallower slope in the target absent condition, indicating that they terminated search earlier. These results suggest that under conditions of high background noise, medicated PD patients were primarily impaired in decision and/or response processes downstream from the target search itself, and that the deficit was attenuated when top-down information was available to guide selection of the target signal. (c) 2006 Elsevier Ltd. All rights reserved.
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