期刊
CHEMBIOCHEM
卷 7, 期 1, 页码 165-173出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200500321
关键词
antiviral agents; glycoproteins; iminocyclitols; inhibitors; osteoarthritis
A novel 5-membered iminocyclitol derivative was found to be a potent and selective inhibitor of the glycoprotein-processing alpha-glucosidase with a K-i value of 53 nM. This compound was further derivatized to antiviral agents against Japanese encephalitis virus, dengue virus serotype 2 (DEN-2), human SARS coronavirus, and human beta-hexosaminidase (K-i = 2.6 rim), a new target for the development of osteoarthritis therapeutics.
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