期刊
INTERNAL MEDICINE
卷 45, 期 20, 页码 1157-1160出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.45.1797
关键词
phosphaturic mesenchyal tumor; tumor-induced osteomalacia fibroblast growth factor 23; octreotide
资金
- Osaka City General Hospital
A 45-year-old man was admitted to our hospital because of bone pain and hypophosphatemia. He had undergone surgery 2 years previously for a benign unclassified mesenchymal tumor in the skull, but there were no clinical symptoms related to osteomalacia. His laboratory examination revealed low serum phosphate, high alkaline phosphatase, and normal calcium levels. The diagnosis of tumor-induced osteomalacia due to phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) was made by reexamining the pathologic specimens. Oral supplementation with phosphate and 1-25-dihydroxyvitamin D relieved his clinical symptoms and laboratory values returned to normal. However, subcutaneous administration of octreotide had no clinical effect. Clinicians and pathologists should be aware of the existence of PMTMCT especially nonphosphaturic or asymptomatic variants of this disorder.
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