期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 63, 期 1, 页码 6-11出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5417-4
关键词
brain serotonin; tryptophan hydroxylase-2 (TPH2); single nucleotide polymorphism (SNP); congenic mice; PC12 cells
资金
- NIMH NIH HHS [MH-40159] Funding Source: Medline
- NINDS NIH HHS [NS-19576] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P30MH040159, P50MH040159] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS019576] Funding Source: NIH RePORTER
Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will summarize some recent findings with respect to the functional analysis of TPH2.
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