期刊
NATURE REVIEWS DRUG DISCOVERY
卷 6, 期 9, 页码 746-762出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2361
关键词
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资金
- NATIONAL CANCER INSTITUTE [P50CA084718] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [P50AA015632, K05AA014715] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA020136, P50DA013333] Funding Source: NIH RePORTER
- NCI NIH HHS [P50CA84718] Funding Source: Medline
- NIAAA NIH HHS [P50AA15632, KO5AA014715] Funding Source: Medline
- NIDA NIH HHS [R01 DA020136, R01DA020136, R01 DA020136-04, P50DA013333] Funding Source: Medline
A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the development of new medications.
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