期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 7, 期 4, 页码 423-432出版社
FUTURE DRUGS LTD
DOI: 10.1586/14737140.7.4.423
关键词
breast neoplasm; chemoprevention; clinical trial; fenretinide; retinoid
类别
Preclinical models suggest that retinoids inhibit mammary carcinogenesis. The induction of apoptosis is a unique feature of fenretinide, the most-studied retinoid in clinical trials of breast cancer chemoprevention, owing to its selective accumulation in breast tissue and its favorable toxicological profile. In a Phase III breast cancer prevention trial, fenretinide showed a strong trend of reduction of incidence of second breast malignancies in premenopausal women, which was confirmed by 15 years of follow-up. This warrants further research on the mechanisms of action and potential efficacy of fenretinide and provides the rationale for a Phase III primary prevention trial in young women at high risk for breast cancer. This review will highlight the role of fenretinide in breast cancer chemoprevention.
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