Studies on novel synthetic methodologies, part 138. One-pot three-component synthesis of alpha-amino nitriles catalyzed by 2,4,6-trichloro-1,3,5-triazine (Cyanuric acid)

A simple and efficient method has been developed for the synthesis of alpha-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.