Solvent inclusion in the structural voids of form II carbamazepine: single-crystal X-ray diffraction, NMR spectroscopy and Hirshfeld surface analysis

Single-crystal X-ray diffraction and solution (HNMR)-H-1 spectroscopy, in conjunction with Hirshfeld surface analysis, give evidence of solvent inclusion in the trigonal polymorph of carbamazepine, which in the unsolvated form is characterised by the presence of large structural voids.