Sensitive determination of clomipramine at poly-ABSA/Pt nano-clusters modified glassy carbon electrode

Clomipramine, an important tricylic antidepressant drug with low redox activity, was effectively electrocatalyzed on poly-aminobenzene sulfonic acid/Pt nano-clusters modified glassy carbon electrode (i.e., poly-ABSA/Pt/GCE) and generated a sensitive anodic peak at about 0.80 V in pH 8.1 PBS. ABSA was electropolymerized on the surface of GCE modified with Pt nano-clusters. Pt nanoparticles provide a 3 D and conductive structure for the polymer immobilization. The resulting sensor exhibited a considerable enhancement in voltammetric response characteristics: extending the linear range and lowering the detection limit. The anodic peak current of clomipramine was linear with its concentration over two concentration intervals, ViZ., 1.0 x 10(-7)similar to 4.0 x 10(-6) M and 4.0 x 10(-6)similar to 4.0 x 10(-5) M, with the detection limit of 1.0 x 10(-9) M (S/N = 3). This method was successfully applied to the determination of clomipramine in drug tablets and proved to be reliable compared with UV.