Cyclopeptides from Sagina japonica (Caryophyllaceae)

Two new cyclic peptides, named sajaponicin C (1) and sajaponicin D (2), were isolated from the whole plants of Sagina japonica (Caryophyllaceae). Their structures were determined as cyclo(Pro(2)- Leu(2)-Tyr-Leu(1)-Phe(1)-Pro(3)-The(2)-Pro(1)) (1) and cyclo (Pro(1)-Pro(2)-Pro(3)-Pro(4)-Phe(1)-Gly-Th r-Ser-Phe(2)-Ile-Tyr) (2) on the basis of spectroscopic data, especially by two-dimensional (213) NMR techniques.