期刊
ARTHRITIS RESEARCH & THERAPY
卷 9, 期 1, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/ar2107
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资金
- NIAMS NIH HHS [R01 AR038477, K01 AR053846, AR38477, K01 AR053846-01A1] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R29AR038477, R01AR038477, K01AR053846] Funding Source: NIH RePORTER
Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis ( RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal models and in patients with RA is also discussed. In light of the overwhelming evidence that disrupted T-cell homeostasis greatly contributes to joint pathology in RA, the therapeutic potential of targeting activators of proinflammatory T cells or their products is compelling.
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