期刊
CANCER RESEARCH
卷 68, 期 1, 页码 18-21出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-07-3234
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- NATIONAL CANCER INSTITUTE [P01CA087969, P50CA089393, R01CA049449, R29CA075016, U01CA049449] Funding Source: NIH RePORTER
- NCI NIH HHS [CA049449, P50 CA089393, CA087969, P50 CA089393-10, U01 CA049449, R01 CA049449, P01 CA087969, CA089393, R01 CA049449-19, CA075016, P01 CA087969-10, R29 CA075016-05] Funding Source: Medline
Colony stimulating factor-1 (CSF1) and its receptor (CSF1-R) are important in mammary gland development and have been implicated in breast carcinogenesis. In a nested case-control study in the Nurses' Heath Study of 726 breast cancer cases diagnosed between June 1, 1992, and June 1, 1998, and 734 matched controls, we prospectively evaluated whether circulating levels of CSF1 (assessed in 1989-1990) are associated with breast cancer risk The association varied by menopausal status (P-heterogeneity = 0.009). CSF1 levels in the highest quartile (versus lowest) were associated with an 85% reduced risk of premenopausal breast cancer [relative risk (RR), 0.15; 95% confidence interval (95% CI), 0.03-0.85; P-trend = 0.02]. In contrast, CSF1 levels in the highest quartile conferred a 33% increased risk of postmenopausal breast cancer (RR, 1.33; 95% CI, 0.96-1.86; P-trend = 0.11), with greatest risk for invasive (RR, 1.45; 95% CI, 1.02-2.07; P-trend = 0.06) and ER+/PR+ tumors (RR, 1.72; 95% CI, 1.11-2.66; P-trend = 0.04). Thus, the association of circulating CSF1 levels and breast cancer varies by menopausal status.
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