期刊
THESCIENTIFICWORLDJOURNAL
卷 7, 期 -, 页码 592-604出版社
THESCIENTIFICWORLD LTD
DOI: 10.1100/tsw.2007.125
关键词
anatomy; embryo; development; imaging; microscopy; avian; quail; MRI
资金
- NCRR NIH HHS [U24 RR021760] Funding Source: Medline
- NHGRI NIH HHS [P50 HG004071] Funding Source: Medline
- NICHD NIH HHS [R21HD047347-01A2] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R21HD047347] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [U24RR021760] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [P50HG004071] Funding Source: NIH RePORTER
We present an archetypal set of three-dimensional digital atlases of the quail embryo based on microscopic magnetic resonance imaging (mu MRI). The atlases are composed of three modules: (1) images of fixed ex ovo quail, ranging in age from embryonic day 5 to 10 (e05 to e10); (2) a coarsely delineated anatomical atlas of the mu MRI data; and (3) an organ system-based hierarchical graph linked to the anatomical delineations. The atlas is designed to be accessed using SHIVA, a free Java application. The atlas is extensible and can contain other types of information including anatomical, physiological, and functional descriptors. It can also be linked to online resources and references. This digital atlas provides a framework to place various data types, such as gene expression and cell migration data, within the normal three-dimensional anatomy of the developing quail embryo. This provides a method for the analysis and examination of the spatial relationships among the different types of information within the context of the entire embryo.
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