期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 22, 期 9, 页码 890-895出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/gps.1759
关键词
dementia with Lewy bodies; cholinesterase inhibitors; donepezil; rivastigmine; galantamine
资金
- Medical Research Council [G0502157, G0400074] Funding Source: Medline
- MRC [G0400074, G0502157] Funding Source: UKRI
Objective To compare efficacy of different cholinesterase inhibitors (ChEls) for treating patients with dementia with Lewy bodies (DLB). Design Retrospective comparison of three independent clinical studies of ChEI treatment using donepezil, galantamine or rivastigmine in patients with DLB. Method Data was obtained from open label trials of donepezil and galantamine and a placebo controlled randomized trial of rivastigmine in DLB. Changes in Mini Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI) and United Parkinson's Disease Rating Scale (UPDRS-III) scores were compared between the three treatments at 12 and 20 weeks. Results All ChEls significantly improved cognitive and neuropsychiatric measures. Reduction in the total NPI score appeared significantly greater after donepezil treatment. There was no significant increase in UPDRS-III scores. Conclusions It is unclear to what extent these findings reflect true differences between ChEls or are due to methodological artefacts of comparing different studies. There is so far no compelling evidence that any one ChEI is better than the other in treating DLB but head to head comparative studies of different ChEls are warranted to clarify this. Copyright (c) 2007 John Wiley & Sons, Ltd.
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