期刊
IMMUNITY
卷 27, 期 3, 页码 493-504出版社
CELL PRESS
DOI: 10.1016/j.immuni.2007.07.019
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资金
- NCI NIH HHS [CA107349-01A1, R01 CA107349] Funding Source: Medline
- NIAID NIH HHS [R01 AI041145, AI041145-07A1, R01 AI041145-09] Funding Source: Medline
- NIDDK NIH HHS [R01 DK099264] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA107349] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041145] Funding Source: NIH RePORTER
The majority of regulatory Foxp3(+)CD4(+) T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4(+) T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery.
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