期刊
NATURE REVIEWS IMMUNOLOGY
卷 7, 期 9, 页码 665-677出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2153
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资金
- NINDS NIH HHS [R01 NS-026543, P01 NS-030871, R01 NS-030871, R01 NS-040460, R01 NS-048411] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040460, R01NS026543, R01NS048411, R01NS030871] Funding Source: NIH RePORTER
The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.
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