期刊
DNA REPAIR
卷 6, 期 4, 页码 443-453出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2006.10.006
关键词
chromatin; base excision repair; XRCCI; PARP; DNA strand break repair
资金
- Medical Research Council [G0300662B] Funding Source: researchfish
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes. (c) 2006 Published by Elsevier B.V.
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