期刊
DNA REPAIR
卷 6, 期 4, 页码 398-409出版社
ELSEVIER
DOI: 10.1016/j.dnarep.2006.10.008
关键词
base damage; dase excision repair; short and long-patch repair
A large variety of DNA lesions induced by environmental agents or arising as an outcome of cellular metabolism are counteracted by a complex network of proteins that belong to the base excision repair/single strand break repair (BER/SSBR) processes. No matter whether the initial lesions are modified DNA bases or single-strand breaks with non-conventional termini these processes are completed either by replacement of a single (short-patch, SP) or more (long-patch, LP) nucleotides by different arrays of proteins. Here, the factors that are involved in the selection between SP- and LP-BER/SSBR are reviewed. The biological significance of these alternative subpathways is also presented as inferred from mutant mouse/cell models. (c) 2006 Elsevier B.V. All rights reserved.
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