期刊
MICROBES AND INFECTION
卷 9, 期 5, 页码 623-628出版社
ELSEVIER
DOI: 10.1016/j.micinf.2007.02.002
关键词
tumor necrosis factor; tuberculosis; reactivation of infection; gene deficient mice
Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflarnmatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis. (c) 2007 Elsevier Masson SAS. All rights reserved.
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