期刊
NATURE REVIEWS NEUROSCIENCE
卷 8, 期 4, 页码 251-261出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2117
关键词
-
Two-pore-domain K+ (K-2P) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels. This structural motif is associated with unusual gating properties, including background channel activity and sensitivity to membrane stretch. Moreover, K-2P channels are modulated by a variety of cellular lipids and pharmacological agents, including polyunsaturated fatty acids and volatile general anaesthetics. Recent in vivo studies have demonstrated that TREK1, the most thoroughly studied K-2P channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据