期刊
PARASITOLOGY
卷 134, 期 -, 页码 453-460出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182006001648
关键词
schistosome; lung schistosomula; immune evasion; in vitro model
类别
资金
- Wellcome Trust [071657] Funding Source: Medline
Past and more recent research has examined the ultrastructure, metabolism, cell biology, genomics and post-genomics of schistosome schistosomula. These areas are considered and discussed in this review with particular emphasis on (1) the early migration phases through the host, (2) interaction of the host immune response with the parasite surface, (3) glucose uptake mechanisms, and (4) defining the transcriptional profiles of lung-stage schistosomula compared with other developmental stages using microarrays. The microarray profiling studies suggest caution is required when considering the use of schistosomes obtained by in vitro means for molecular or biochemical Studies.
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