期刊
NATURE REVIEWS GENETICS
卷 8, 期 1, 页码 35-46出版社
NATURE RESEARCH
DOI: 10.1038/nrg2008
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资金
- Intramural NIH HHS Funding Source: Medline
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.
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