期刊
CEREBROVASCULAR DISEASES
卷 23, 期 1, 页码 46-49出版社
KARGER
DOI: 10.1159/000095758
关键词
aneurysm, intracranial; alpha-1-antichymotrypsin; SERPINA3; subarachnoid hemorrhage; polymorphism
Background: Serine protease inhibitor member 3 of clade A ( SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G ( proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage ( SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population. Methods: A total of 437 patients with an aneurysmal SAH and 405 control cases of Japanese origin were genotyped for the A15T polymorphism and 2 further intronic single nucleotide polymorphisms by using polymerase chain reaction and direct sequencing. Results: In the patients with intracranial aneurysms the SERPINA3 A15T allele and genotype distribution did not differ significantly from the controls. Conclusion: In the Japanese population the A15T polymorphism of the SERPINA3 gene is not associated with aneurysmal SAH. Copyright (c) 2007 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据