期刊
NATURE REVIEWS IMMUNOLOGY
卷 7, 期 1, 页码 31-40出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1997
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The NOD-like receptors have important roles in innate immunity as intracellular sensors of microbial components and cell injury. It has been proposed that these cytosolic proteins regulate the cysteine protease caspase-1 within a multiprotein complex known as the 'inflammasome'. Activation of caspase-1 leads to the cleavage and activation of proinflammatory cytokines such as interleukin-1 beta (IL-1 beta) and IL-18, as well as host-cell death. The analysis of mice that are deficient in various inflammasome components has revealed that the inflammasome is a dynamic entity that is assembled from different adaptors in a stimulus-dependent manner. Here we review recent work on the activation of the inflammasome in response to various bacterial pathogens and tissue damage.
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