期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 8, 期 1, 页码 49-62出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2083
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资金
- Wellcome Trust Funding Source: Medline
Nuclear factor (NF)-kappa B and inhibitor of NF-kappa B kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappa B or IKK function contributes to many human diseases, including cancer. However, the NF-kappa B and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappa B and IKK activation and, ultimately, cell fate.
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