期刊
PHYTOMEDICINE
卷 14, 期 -, 页码 32-39出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2006.11.019
关键词
Pelargonium sidoides; mass spectroscopy; aminoconjugates; oligomers; proanthocyanidins; chromatography; behavioural activities
Chromatographic fractionation of proanthocyanidin oligomers from an aqueous ethanolic extract of Pelargonium sidoides roots (EPs (R) 7630) gave a diverse set of epigallo- and gallocatechin based oligomers, which are connected by A and B-type bonds. Additionally, two series of monosubstituted oligomers were detected by mass spectroscopy, sulphates and aminoconjugates. In vivo studies investigating motility, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities, showed no or only moderate pharmacological effects, indicating, that they have no intrinsic behavioural activities. (c) 2006 Elsevier GmbH. All rights reserved.
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